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OBAT-OBATSISTEM
KARDIOVASKULAR
RIF
KA
NURUL
UTAMI
LABORATORIU
M F
ARMAKOLOGI TOK
SIK
OLOGI
FAKULT
AS
FARMASI
UNHAS
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Before we start this lesson....
Bagian jantng !ana"ah #ang $erfngsi nt" !e!o!%a &arah "eselrh t$h '() res%on* (+, ji"a $isa !en#e$t"an istilah latinn#a
er$e&aan antara aorta/ arteri "oroner/ arteri/ arteriola '(+, res%on
er$e&aan antara 0ena 1a0a/ 0ena/ 0enla/ 0ena "ar&ia" '(+, res%on
er$e&aan antara sir"lasi %l!onar &an sir"lasi siste!i"* $er&asar"anjenis %e!$lh &an "an&ngan o"sigen &ala! &arah '(2, res%on ata(+, jian a"hir
Me"anis!e "on&"si %otensial a"si jantng '(3, res%on ata (2, jian
a"hir
Detail !engenai siste! RAA &an "aitann#a &engan te"anan &arah '(),res%on ata (3, jian a"hir
Mini!al ) golongan o$at-o$at #ang !a!% !e!%engarhi siste!"ar&io0as"lar $eserta !e"anis!e "erjan#a '(3, res%on ata (+)jian a"hir
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e!$lh 4a&i e!$lh Bali"
Aorta Arteri Arteriola Arteri koroner
Arteri pulmonaris
Vena caa Vena Venula Vena koroner !ena
sinus" Vena pulmonaris
Ka%iler
5enis e!$lh Darah
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Tekanan #ara$
Baroreseptor %an
peran&san&ansimpatis
'ura$ (antun&
Vasokontriksi
#en)ut
Sistem RAA Resistensi peri*er
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+,NGGOL
ONGAN
OBAT
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DIURETIK
6olongan Me"anis!e Kerja 7ontoh O$at
Tia-i%
Men&$am.attransport natrium %anklori%a pa%a tu.ulus
%istal &in(al ekskresi menin&kat
Hi%roklorotia-i%/klorotia-o%
Loop !#iuretik kuat"Men&$am.at am.ilankem.ali Na0/ K0/ 'l1
air %an elektrolitFurosemi%/ torasemi%
Hemat kalium!Potassium-sparring
diuretic"
Menin&katkan ekskresinatrium %an klori%a2
menunrunkan eksreksikalium
Amilori%/triamteren
Spironolakton !(u&amemiliki e*ek
se.a&ai anta&onis
al%osteron"
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+en&$am.at
A%rener&ik
1.locker
Kar%ioselekti*
Nonselekti*
1.locker
A%renolitiksentral
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Vaso%ilator
Hi%rala-in
Monoksi%il
#ia-oksi%
Natriumnitroprusi%
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