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Keseimbangan Nitrogen

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  • Ana AndrianaBAGIAN BIOKIMIA FK UNIZARKESEIMBANGAN NITROGEN

  • Nitrogen balance - Ana

    PENDAHULUAN

    Nitrogen balance - Ana

  • Protein Metabolism - AnaPROTEINSuatu senyawa yg disusun oleh dua atau lebih asam amino yang dihubungkan melalui ikatan peptida +H2N OH + HNH

    Protein Metabolism - Ana

  • Protein Metabolism - Ana IKATAN PEPTIDAADALAH IKATAN ANTARA GUGUS KARBOKSIL DARI SATU ASAM AMINO DENGAN GUGUSAN AMINA DARI ASAM AMINO YANG LAINHNO+H3NOSHO -NHO

    Protein Metabolism - Ana

  • Protein Metabolism - Ana

    Protein Metabolism - Ana

  • Protein Metabolism - Ana

    Protein Metabolism - Ana

  • Protein Metabolism - AnaASAM AMINOUnit terkecil penyusun proteinBersifat amfoter

    Protein Metabolism - Ana

  • Protein Metabolism - AnaFUNGSI Membentuk dan mempertahankan struktur sel (kestabilan mekanik ; kolagen)Transport oksigen (Hb)Perlindungan dan pertahanan (Ig, fibrinogen)Pengendali dan pengatur (sbg pembawa sinyal)Katalisator (enzim)Pergerakan (aktin miosin)Penghasil energi (oksidasi kerangka karbon)

    Protein Metabolism - Ana

  • Protein Metabolism - AnaSTRUKTUR - FUNGSIBentuk menentukan fungsiContoh : kolagen (25%) pada mamalia Menggambarkan keaneka ragaman struktur dan fungsi.- Kolagen kulit : serabut yg terpintal dan fleksible- Kolagen pada gigi dan tulang: kekuatan gigi- Kolagen pada kornea : spt kristal (tembus pandang)

    Protein Metabolism - Ana

  • Protein Metabolism - AnaPROTEIN STRUCTUREPRIMARY STRUCTURE: amino acids sequenceSECONDARY STRUCTURE:alpha helix, beta sheetsTERTIARY STRUCTURE:disulfide bondsQUATERNARY STRUCTURE: >1 polypeptide

    Protein Metabolism - Ana

  • Protein Metabolism - AnaKLASIFIKASI ASAM AMINODitinjau dari struktur kimianya aa dibagi aa netral, aa bersifat asam, aa bersifat basa.Dari aspek kepentingan gizi aa essensial dan non essensial.Aspek jalur metab yg ditempuh aa ketogenik, aa gliko-ketogenik, dan aa glikogenik

    Protein Metabolism - Ana

  • Protein Metabolism - Ana

    Protein Metabolism - Ana

  • Protein Metabolism - AnaNon essentialEssential

    Protein Metabolism - Ana

  • Protein Metabolism - AnaBerdasarkan jalur metabolisme yg ditempuhKetogenik : Dioksidasi dgn menempuh jalur oksidasi lemak sajaGlikogenik : Dioksidasi dgn menempuh jalur Karbohidrat sajaGlikoketogenik : Jalur oksidasi Karbohidrat maupun lemak

    Protein Metabolism - Ana

  • Protein Metabolism - Ana

    GlikogenikKetogenikGlikoketogenikAsparaginAspartatSisteinTriptofanGlisinSerinAlanin ValinMetioninArgininProlinAsam glutamatGlutaminHistidin LisinLeusin FenilalaninTirosinIsoleusin

    Protein Metabolism - Ana

  • Protein Metabolism - AnaKEY REACTIONS OF AMINO ACID METABOLISMTRANSAMINATION converts one aa into another

    OXIDATIVE DEAMINATION removes the amino group

    Protein Metabolism - Ana

  • Protein Metabolism - AnaCATABOLISM

    Protein Metabolism - Ana

  • Protein Metabolism - AnaDIGESTION & ABSORPTIONPEPTIDASES:EnteropeptidaseExopeptidase (amino, carboxypeptidase) STOMACHPepsin carboxyl group, low pHSMALL INTESTINE :Pancreatic secretion: trypsin, chemotrypsin, elastase andcarboxypeptidase

    Protein Metabolism - Ana

  • Protein Metabolism - AnaDIGESTION & ABSORPTION

    Protein Metabolism - Ana

  • Protein Metabolism - Ana

    Protein Metabolism - Ana

  • Protein Metabolism - AnaRELATIONSHIP TO CENTRAL METABOLISM

    Protein Metabolism - Ana

  • Protein Metabolism - AnaKatabolisme asam aminoKomponen Nitrogen.Pengeluaran Nitrogen dari asam amino, secara transaminasi dan deaminasi oksidatif untuk menghasilkan ammonia dan asam ketoSiklus urea untuk merubah ammonia yg bersifat toksisKomponen kerangka karbon.Metabolisme asam keto melalui siklus Krebs (siklus asam trikarboksilat)

    Protein Metabolism - Ana

  • Protein Metabolism - Ana

    Protein Metabolism - Ana

  • Protein Metabolism - AnaThe urea cycle consists offive reactions that synthesize the organic compound urea from two inorganic compounds: CO2 and NH4+

    UREA CYCLE

    Protein Metabolism - Ana

  • Protein Metabolism - Ana

    Protein Metabolism - Ana

  • Protein Metabolism - AnaNITROGEN BALANCEINGESTION = SECRETIONPOSITIF Peningkatan sintesis protein pertumbuhan, pemulihan NEGATIFPeningkatan degradasi protein malnutrition, fasting, starvation

    Protein Metabolism - Ana

  • Protein Metabolism - AnaAmino acid pool in the body is in dynamic equilibrium with tissue proteins.

    Protein Metabolism - Ana

  • Protein Metabolism - AnaKATABOLISME KERANGKA KARBONCarbon skeletons of aa can be metabolized to intermediates of the TCA cycle and glycolytic pathwayProduce 7 products: pyruvate, acetyl CoA, acetoacetyl CoA, -ketoglutarate, succinyl CoA , fumarate, oxaloacetate

    Protein Metabolism - Ana

  • Protein Metabolism - Ana

    Protein Metabolism - Ana

  • Protein Metabolism - AnaKATABOLISME KERANGKA KARBONGLUCOGENIC:aspartic acid, glutamic acid, asparagine,glutamine, histidine, proline, arginine, glycine, alanine, serine, cysteine, methonine, valine

    Protein Metabolism - Ana

  • Protein Metabolism - AnaKATABOLISME KERANGKA KARBONKETOGENIC: leucine, lysine

    GLUCO AND KETOGENIC:Phenylalanine, tyrosine, tryptophan,isoleucine, threonine

    Protein Metabolism - Ana

  • Protein Metabolism - AnaANABOLISM

    Protein Metabolism - Ana

  • Protein Metabolism - AnaAMINO ACID BIOSYNTHESISESSENTIAL AA NON-ESSENTIAL AA

    Protein Metabolism - Ana

  • Protein Metabolism - Ana

    Protein Metabolism - Ana

  • Protein Metabolism - Ana

    Protein Metabolism - Ana

  • Protein Metabolism - Ana

    Protein Metabolism - Ana

  • Protein Metabolism - AnaKONVERSI AA MENJADI PRODUK KHUSUSProduk yang berasal dari AA:PurinesPyrimidinesHormonesNeurotransmitterHistamineGLYCINE: biosynthesis heme, purines and creatineNEUROTRANSMITTER (GABA)glutamate dan ornithineHISTIDIN histamineTRYPTHOPAN: serotonin, melanin, melatoninTYROSINE: epinephrine, nor.E

    Protein Metabolism - Ana

  • Protein Metabolism - Ana

    Protein Metabolism - Ana

  • Protein Metabolism - Ana

    Protein Metabolism - Ana

  • Terima kasih

    *****

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