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IMUNOLOGIIMUNOLOGI

Dr. SUPARYANTO, M.KesDr. SUPARYANTO, M.Kes

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APA ITU IMUNOLOGI?APA ITU IMUNOLOGI?

Imunologi: Ilmu yng mem!el"riImunologi: Ilmu yng mem!el"ri

#en#ng sis#em imun #u$u%#en#ng sis#em imun #u$u%

Sis#em imun : Semu me&nisme ygSis#em imun : Semu me&nisme yg'igun&n #u$u% se$gi'igun&n #u$u% se$gi

!erlin'ungn #er%'! $%y yg!erlin'ungn #er%'! $%y yg

'!# 'i#im$ul&n $er$gi $%n'!# 'i#im$ul&n $er$gi $%n

'lm ling&ungn %i'u!'lm ling&ungn %i'u!

Ling&ungn: (isi&, &imi, $iologiLing&ungn: (isi&, &imi, $iologi

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MA)AM SIST*M IMUNMA)AM SIST*M IMUN

+.+. Sis#em imun lmi% nonSis#em imun lmi% non

s!esi(i& n#ure inn#es!esi(i& n#ure inn#e

-.-. Sis#em imun 'i'!# s!esi(i&Sis#em imun 'i'!# s!esi(i&'!#i( /uire''!#i( /uire'

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SIST*M IMUN ALAMIA0SIST*M IMUN ALAMIA0

Si(# non s!esi(i&: r#iny mem$eri&nSi(# non s!esi(i&: r#iny mem$eri&n!erlin'ungn &e!' semu!erlin'ungn &e!' semu$%nling&ungn yg mengnm #u$u%$%nling&ungn yg mengnm #u$u%

Di'!# se"& l%irDi'!# se"& l%ir Res!on e!#Res!on e!# #i'& !erlu 1u#i'& !erlu 1u

un#u& mengenl n#igenun#u& mengenl n#igen

Di$e'&n 2 mmDi$e'&n 2 mm 3isi&3isi&

Lru#nLru#n

SelulerSeluler

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MA)AM SIST*M IMUN NON SP*SI3IKMA)AM SIST*M IMUN NON SP*SI3IK

+.+. 3isi& Me&ni&3isi& Me&ni&

Kuli#Kuli#

Sel!u# len'irSel!u# len'ir

SiliSili

4#u&4#u&

4ersin4ersin

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MA)AM SIST*M IMUN NON SP*SI3IKMA)AM SIST*M IMUN NON SP*SI3IK

-.-. Lru#nLru#n

4io&imi: Asm lm$ung,4io&imi: Asm lm$ung,

Sli5, )irn 5ginSli5, )irn 5gin 0umorl: Kom!lemen,0umorl: Kom!lemen,

In#er(eron, )6Rei(In#er(eron, )6Rei(

Pro#einPro#ein

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MA)AM SIST*M IMUN NON SP*SI3IKMA)AM SIST*M IMUN NON SP*SI3IK

2.2. SelulerSeluler

3gosi#: Leu&osi# 7Neu#ro(il,3gosi#: Leu&osi# 7Neu#ro(il,

*osino(il, Monosi#, M&ro(g8*osino(il, Monosi#, M&ro(g8

Sel Nol 7Lrge GrnulrSel Nol 7Lrge GrnulrLym!%oy#e8: N#url Killer )ellLym!%oy#e8: N#url Killer )ell

7sel NK8, Killer )ell 7sel K87sel NK8, Killer )ell 7sel K8

Sel Me'i#or: 4so(il, Ms#osi#,Sel Me'i#or: 4so(il, Ms#osi#,

Trom$osi#Trom$osi#

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SIST*M IMUN SP*SI3IKSIST*M IMUN SP*SI3IK

Si(# s!esi(i&: r#inySi(# s!esi(i&: r#iny

mem$eri&n !erlin'ungnmem$eri&n !erlin'ungn

%ny &e!' "enis n#igen%ny &e!' "enis n#igen

#er#en#u, #i'& un#u& yg liny.#er#en#u, #i'& un#u& yg liny.

Di!erole% 'engn "ln:Di!erole% 'engn "ln:

imunissi, s&i#, #u 'ri i$uimunissi, s&i#, #u 'ri i$u

le1# !lsen#, ASIle1# !lsen#, ASI

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SIST*M IMUN SP*SI3IKSIST*M IMUN SP*SI3IK

Un#u& men'!#&ny !erluUn#u& men'!#&ny !erlu

1u1u r#iny #u$u% !erlur#iny #u$u% !erlu

mengenl 'ulu n#igen #s$mengenl 'ulu n#igen #s$ selsel

imun sensi#i(siimun sensi#i(si !ro'u&si!ro'u&si

&e&e$ln&e&e$ln

Ke&e$ln $ru $er(ungsiKe&e$ln $ru $er(ungsi !'!'

s# #er!!r n#igen yg &e'us# #er!!r n#igen yg &e'u

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MA)AM S*L IMUNMA)AM S*L IMUN

SP*SI3IKSP*SI3IK

+.+. 0umorl: Lim(osi# 40umorl: Lim(osi# 4 sel 4sel 4

n#i$o'in#i$o'i

-.-. Seluler: Lim(osi# TSeluler: Lim(osi# T sel Tsel T

5irus, "mur, !rsi#, &egnsn5irus, "mur, !rsi#, &egnsn

2.2. Sis#em Lim(oi': Kel. Timus,Sis#em Lim(oi': Kel. Timus,

Lim!, &el. Lim(e 7#onsil8Lim!, &el. Lim(e 7#onsil8

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MA)AM S*L IMUN SP*SI3IKMA)AM S*L IMUN SP*SI3IK

+.+. MALT 7Muosl Assoi#e'MALT 7Muosl Assoi#e'

Lym!%oi' Tissue8Lym!%oi' Tissue8 slurnslurn

n(s, ern, geni#ln(s, ern, geni#l

-.-. SALT 7S&in Assoi#e' Lym!%oi'SALT 7S&in Assoi#e' Lym!%oi'

Tissue8Tissue8 Ker#inoi', melnosi',Ker#inoi', melnosi',

sel Lnger%ns, &olgensel Lnger%ns, &olgen

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APA ITU ANTIG*NAPA ITU ANTIG*N

An#igen: $%n yng '!#An#igen: $%n yng '!#

merngsng res!on imun 'nmerngsng res!on imun 'n

'!# $ere&si 'engn n#i$o'i'!# $ere&si 'engn n#i$o'i

Mm An#igen:Mm An#igen:

+.+. Imunogen: $%n yg '!#Imunogen: $%n yg '!#

merngsng res!on imunmerngsng res!on imun

-.-. 0!#en: $%n yg '!# $ere&si0!#en: $%n yg '!# $ere&si

'engn n#i$o'i'engn n#i$o'i

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APA ITU *PITOP DAN PARATOPAPA ITU *PITOP DAN PARATOP

*!i#o!De#erminn*!i#o!De#erminn $gin 'ri$gin 'ri

n#igen yg '!# mengenln#igen yg '!# mengenl

mengin'u&si !em$enn#u&nmengin'u&si !em$enn#u&n

n#i$o'in#i$o'i

Pr#o!Pr#o! $gin 'ri n#i$o'i yg$gin 'ri n#i$o'i yg

'!# mengi e!i#o!'!# mengi e!i#o!

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MA)AM ANTIG*N 4*RDASAR *PITOPMA)AM ANTIG*N 4*RDASAR *PITOP

+.+. Uni'e#erminn, uni5lenUni'e#erminn, uni5len "enis"enis

e!i#o! s#u 'n "uml%ny s#ue!i#o! s#u 'n "uml%ny s#u

999999999999999999999999999999999999999999999999999999

-.-. Uni'e#erminn, mul#i5lenUni'e#erminn, mul#i5len "enis"enis

e!i#o! s#u, "uml% le$i% 'ri s#ue!i#o! s#u, "uml% le$i% 'ri s#u

999999999999999999999999999999999999999999999999999999999999

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MA)AM ANTIG*N 4*RDASAR *PITOPMA)AM ANTIG*N 4*RDASAR *PITOP

2.2. Mul#i'e#erminn, uni5lenMul#i'e#erminn, uni5len

"enis e!i#o! le$i% 'ri s#u 'n"enis e!i#o! le$i% 'ri s#u 'n

"uml%ny s#u"uml%ny s#u

999;999

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MA)AM ANTIG*N 4*RDASAR SP*SI3ISITASMA)AM ANTIG*N 4*RDASAR SP*SI3ISITAS

+.+. 0e#eron#igen0e#eron#igen 'imili&i $ny& s!esies'imili&i $ny& s!esies

-.-. enon#igenenon#igen 'imili&i s!esies #er#en#u'imili&i s!esies #er#en#u

2.2. Allon#igenAllon#igen 'imili&i s#u s!esies'imili&i s#u s!esies

=.=. An#igen orgn s!esi(i&An#igen orgn s!esi(i& 'imili&i orgn'imili&i orgn

#er#en#u#er#en#u

@.@. Au#on#igenAu#on#igen $ersl 'ri #u$u%ny$ersl 'ri #u$u%ny

sen'irisen'iri

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MA)AM ANTIG*N 4*RDASARMA)AM ANTIG*N 4*RDASAR

K*T*RGANTUNGAN S*L TK*T*RGANTUNGAN S*L T

+.+. T 'e!en'enT 'e!en'en !erlu !engenln!erlu !engenln

#%' sel T 'n sel 4#%' sel T 'n sel 4 un#u&un#u&

merngsng n#i$o'imerngsng n#i$o'i

-.-. T In'e!en'enT In'e!en'en '!# merngsng'!# merngsng

sel 4 #n! mengenl sel Tsel 4 #n! mengenl sel T

'%ulu'%ulu

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MA)AM ANTIG*N 4*RDASARMA)AM ANTIG*N 4*RDASAR

4A0AN KIMIANYA4A0AN KIMIANYA

+.+. Kr$o%i'r#Kr$o%i'r# imunogeni&imunogeni&

-.-. Li!i': #i'& imunogeni&Li!i': #i'& imunogeni&

%!#en%!#en

2.2. Asm nu&le#Asm nu&le# #i'i'&

imunogeni&imunogeni&

=.=. Pro#einPro#ein imunogeni&imunogeni&

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APA ITU ANTI4ODIAPA ITU ANTI4ODI

An#i$o'iAn#i$o'i !ro#ein serum yng!ro#ein serum yng

mem!unyi res!on imun 7&e&e$ln8mem!unyi res!on imun 7&e&e$ln8

!' #u$u%!' #u$u% Imunoglo$ulin 7Ig8Imunoglo$ulin 7Ig8

Ig 'i$en#u& ole% sel !lsm 7!roli(ersiIg 'i$en#u& ole% sel !lsm 7!roli(ersisel 48 &i$# &on#&'irngsng ole%sel 48 &i$# &on#&'irngsng ole%

n#igenn#igen

Mm Imunoglo$ulin: Ig G, Ig A, IgMm Imunoglo$ulin: Ig G, Ig A, Ig

M, Ig *, Ig DM, Ig *, Ig D

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IMUNOGLO4ULIN GIMUNOGLO4ULIN G

Ter$ny& 'lm serum 7@B8Ter$ny& 'lm serum 7@B8

D!# menem$us !lsen#D!# menem$us !lsen# mem$en#u&mem$en#u&

imuni#s $yi sm!i $erumur C6 $ulnimuni#s $yi sm!i $erumur C6 $uln

Mem!unyi si(# o!soninMem!unyi si(# o!sonin $er%u$ungn$er%u$ungn

er# 'engn (gosi#, monosi# 'n m&ro(ger# 'engn (gosi#, monosi# 'n m&ro(g

4er!ern !' imuni#s seluler4er!ern !' imuni#s seluler '!#'!#

merus& n#igen selulermerus& n#igen seluler $erin#er&si$erin#er&si'engn &om!lemen, sel K, eosino(il 'n'engn &om!lemen, sel K, eosino(il 'n

neu#ro(ilneu#ro(il

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IMUNOGLO4ULIN AIMUNOGLO4ULIN A

Se'i&i# 'lm serumSe'i&i# 'lm serum

4ny& #er'!# 'lm4ny& #er'!# 'lm slurn n(s,slurn n(s,

ern, &emi%, ir m#, &ering#, lu'% 'nern, &emi%, ir m#, &ering#, lu'% 'n

ir susuir susu 3ungsi3ungsi

Mene#rl&n #o&sin 'n 5irus,Mene#rl&n #o&sin 'n 5irus,

Meneg% &on#& n#r #o&sin 5irus 'ng selMeneg% &on#& n#r #o&sin 5irus 'ng sel

ssrnssrn

Mengum!l&n menggnggu ger& &umnMengum!l&n menggnggu ger& &umn

memu'%&n (gosi#osismemu'%&n (gosi#osis

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