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Dr.suparyanto Imunologi

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    IMUNOLOGIIMUNOLOGI

    Dr. SUPARYANTO, M.KesDr. SUPARYANTO, M.Kes

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    APA ITU IMUNOLOGI?APA ITU IMUNOLOGI?

    Imunologi: Ilmu yng mem!el"riImunologi: Ilmu yng mem!el"ri

    #en#ng sis#em imun #u$u%#en#ng sis#em imun #u$u%

    Sis#em imun : Semu me&nisme ygSis#em imun : Semu me&nisme yg'igun&n #u$u% se$gi'igun&n #u$u% se$gi

    !erlin'ungn #er%'! $%y yg!erlin'ungn #er%'! $%y yg

    '!# 'i#im$ul&n $er$gi $%n'!# 'i#im$ul&n $er$gi $%n

    'lm ling&ungn %i'u!'lm ling&ungn %i'u!

    Ling&ungn: (isi&, &imi, $iologiLing&ungn: (isi&, &imi, $iologi

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    MA)AM SIST*M IMUNMA)AM SIST*M IMUN

    +.+. Sis#em imun lmi% nonSis#em imun lmi% non

    s!esi(i& n#ure inn#es!esi(i& n#ure inn#e

    -.-. Sis#em imun 'i'!# s!esi(i&Sis#em imun 'i'!# s!esi(i&'!#i( /uire''!#i( /uire'

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    SIST*M IMUN ALAMIA0SIST*M IMUN ALAMIA0

    Si(# non s!esi(i&: r#iny mem$eri&nSi(# non s!esi(i&: r#iny mem$eri&n!erlin'ungn &e!' semu!erlin'ungn &e!' semu$%nling&ungn yg mengnm #u$u%$%nling&ungn yg mengnm #u$u%

    Di'!# se"& l%irDi'!# se"& l%ir Res!on e!#Res!on e!# #i'& !erlu 1u#i'& !erlu 1u

    un#u& mengenl n#igenun#u& mengenl n#igen

    Di$e'&n 2 mmDi$e'&n 2 mm 3isi&3isi&

    Lru#nLru#n

    SelulerSeluler

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    MA)AM SIST*M IMUN NON SP*SI3IKMA)AM SIST*M IMUN NON SP*SI3IK

    +.+. 3isi& Me&ni&3isi& Me&ni&

    Kuli#Kuli#

    Sel!u# len'irSel!u# len'ir

    SiliSili

    4#u&4#u&

    4ersin4ersin

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    MA)AM SIST*M IMUN NON SP*SI3IKMA)AM SIST*M IMUN NON SP*SI3IK

    -.-. Lru#nLru#n

    4io&imi: Asm lm$ung,4io&imi: Asm lm$ung,

    Sli5, )irn 5ginSli5, )irn 5gin 0umorl: Kom!lemen,0umorl: Kom!lemen,

    In#er(eron, )6Rei(In#er(eron, )6Rei(

    Pro#einPro#ein

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    MA)AM SIST*M IMUN NON SP*SI3IKMA)AM SIST*M IMUN NON SP*SI3IK

    2.2. SelulerSeluler

    3gosi#: Leu&osi# 7Neu#ro(il,3gosi#: Leu&osi# 7Neu#ro(il,

    *osino(il, Monosi#, M&ro(g8*osino(il, Monosi#, M&ro(g8

    Sel Nol 7Lrge GrnulrSel Nol 7Lrge GrnulrLym!%oy#e8: N#url Killer )ellLym!%oy#e8: N#url Killer )ell

    7sel NK8, Killer )ell 7sel K87sel NK8, Killer )ell 7sel K8

    Sel Me'i#or: 4so(il, Ms#osi#,Sel Me'i#or: 4so(il, Ms#osi#,

    Trom$osi#Trom$osi#

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    SIST*M IMUN SP*SI3IKSIST*M IMUN SP*SI3IK

    Si(# s!esi(i&: r#inySi(# s!esi(i&: r#iny

    mem$eri&n !erlin'ungnmem$eri&n !erlin'ungn

    %ny &e!' "enis n#igen%ny &e!' "enis n#igen

    #er#en#u, #i'& un#u& yg liny.#er#en#u, #i'& un#u& yg liny.

    Di!erole% 'engn "ln:Di!erole% 'engn "ln:

    imunissi, s&i#, #u 'ri i$uimunissi, s&i#, #u 'ri i$u

    le1# !lsen#, ASIle1# !lsen#, ASI

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    SIST*M IMUN SP*SI3IKSIST*M IMUN SP*SI3IK

    Un#u& men'!#&ny !erluUn#u& men'!#&ny !erlu

    1u1u r#iny #u$u% !erlur#iny #u$u% !erlu

    mengenl 'ulu n#igen #s$mengenl 'ulu n#igen #s$ selsel

    imun sensi#i(siimun sensi#i(si !ro'u&si!ro'u&si

    &e&e$ln&e&e$ln

    Ke&e$ln $ru $er(ungsiKe&e$ln $ru $er(ungsi !'!'

    s# #er!!r n#igen yg &e'us# #er!!r n#igen yg &e'u

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    MA)AM S*L IMUNMA)AM S*L IMUN

    SP*SI3IKSP*SI3IK

    +.+. 0umorl: Lim(osi# 40umorl: Lim(osi# 4 sel 4sel 4

    n#i$o'in#i$o'i

    -.-. Seluler: Lim(osi# TSeluler: Lim(osi# T sel Tsel T

    5irus, "mur, !rsi#, &egnsn5irus, "mur, !rsi#, &egnsn

    2.2. Sis#em Lim(oi': Kel. Timus,Sis#em Lim(oi': Kel. Timus,

    Lim!, &el. Lim(e 7#onsil8Lim!, &el. Lim(e 7#onsil8

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    MA)AM S*L IMUN SP*SI3IKMA)AM S*L IMUN SP*SI3IK

    +.+. MALT 7Muosl Assoi#e'MALT 7Muosl Assoi#e'

    Lym!%oi' Tissue8Lym!%oi' Tissue8 slurnslurn

    n(s, ern, geni#ln(s, ern, geni#l

    -.-. SALT 7S&in Assoi#e' Lym!%oi'SALT 7S&in Assoi#e' Lym!%oi'

    Tissue8Tissue8 Ker#inoi', melnosi',Ker#inoi', melnosi',

    sel Lnger%ns, &olgensel Lnger%ns, &olgen

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    APA ITU ANTIG*NAPA ITU ANTIG*N

    An#igen: $%n yng '!#An#igen: $%n yng '!#

    merngsng res!on imun 'nmerngsng res!on imun 'n

    '!# $ere&si 'engn n#i$o'i'!# $ere&si 'engn n#i$o'i

    Mm An#igen:Mm An#igen:

    +.+. Imunogen: $%n yg '!#Imunogen: $%n yg '!#

    merngsng res!on imunmerngsng res!on imun

    -.-. 0!#en: $%n yg '!# $ere&si0!#en: $%n yg '!# $ere&si

    'engn n#i$o'i'engn n#i$o'i

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    APA ITU *PITOP DAN PARATOPAPA ITU *PITOP DAN PARATOP

    *!i#o!De#erminn*!i#o!De#erminn $gin 'ri$gin 'ri

    n#igen yg '!# mengenln#igen yg '!# mengenl

    mengin'u&si !em$enn#u&nmengin'u&si !em$enn#u&n

    n#i$o'in#i$o'i

    Pr#o!Pr#o! $gin 'ri n#i$o'i yg$gin 'ri n#i$o'i yg

    '!# mengi e!i#o!'!# mengi e!i#o!

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    MA)AM ANTIG*N 4*RDASAR *PITOPMA)AM ANTIG*N 4*RDASAR *PITOP

    +.+. Uni'e#erminn, uni5lenUni'e#erminn, uni5len "enis"enis

    e!i#o! s#u 'n "uml%ny s#ue!i#o! s#u 'n "uml%ny s#u

    999999999999999999999999999999999999999999999999999999

    -.-. Uni'e#erminn, mul#i5lenUni'e#erminn, mul#i5len "enis"enis

    e!i#o! s#u, "uml% le$i% 'ri s#ue!i#o! s#u, "uml% le$i% 'ri s#u

    999999999999999999999999999999999999999999999999999999999999

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    MA)AM ANTIG*N 4*RDASAR *PITOPMA)AM ANTIG*N 4*RDASAR *PITOP

    2.2. Mul#i'e#erminn, uni5lenMul#i'e#erminn, uni5len

    "enis e!i#o! le$i% 'ri s#u 'n"enis e!i#o! le$i% 'ri s#u 'n

    "uml%ny s#u"uml%ny s#u

    999;999

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    MA)AM ANTIG*N 4*RDASAR SP*SI3ISITASMA)AM ANTIG*N 4*RDASAR SP*SI3ISITAS

    +.+. 0e#eron#igen0e#eron#igen 'imili&i $ny& s!esies'imili&i $ny& s!esies

    -.-. enon#igenenon#igen 'imili&i s!esies #er#en#u'imili&i s!esies #er#en#u

    2.2. Allon#igenAllon#igen 'imili&i s#u s!esies'imili&i s#u s!esies

    =.=. An#igen orgn s!esi(i&An#igen orgn s!esi(i& 'imili&i orgn'imili&i orgn

    #er#en#u#er#en#u

    @[email protected] Au#on#igenAu#on#igen $ersl 'ri #u$u%ny$ersl 'ri #u$u%ny

    sen'irisen'iri

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    MA)AM ANTIG*N 4*RDASARMA)AM ANTIG*N 4*RDASAR

    K*T*RGANTUNGAN S*L TK*T*RGANTUNGAN S*L T

    +.+. T 'e!en'enT 'e!en'en !erlu !engenln!erlu !engenln

    #%' sel T 'n sel 4#%' sel T 'n sel 4 un#u&un#u&

    merngsng n#i$o'imerngsng n#i$o'i

    -.-. T In'e!en'enT In'e!en'en '!# merngsng'!# merngsng

    sel 4 #n! mengenl sel Tsel 4 #n! mengenl sel T

    '%ulu'%ulu

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    MA)AM ANTIG*N 4*RDASARMA)AM ANTIG*N 4*RDASAR

    4A0AN KIMIANYA4A0AN KIMIANYA

    +.+. Kr$o%i'r#Kr$o%i'r# imunogeni&imunogeni&

    -.-. Li!i': #i'& imunogeni&Li!i': #i'& imunogeni&

    %!#en%!#en

    2.2. Asm nu&le#Asm nu&le# #i'i'&

    imunogeni&imunogeni&

    =.=. Pro#einPro#ein imunogeni&imunogeni&

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    APA ITU ANTI4ODIAPA ITU ANTI4ODI

    An#i$o'iAn#i$o'i !ro#ein serum yng!ro#ein serum yng

    mem!unyi res!on imun 7&e&e$ln8mem!unyi res!on imun 7&e&e$ln8

    !' #u$u%!' #u$u% Imunoglo$ulin 7Ig8Imunoglo$ulin 7Ig8

    Ig 'i$en#u& ole% sel !lsm 7!roli(ersiIg 'i$en#u& ole% sel !lsm 7!roli(ersisel 48 &i$# &on#&'irngsng ole%sel 48 &i$# &on#&'irngsng ole%

    n#igenn#igen

    Mm Imunoglo$ulin: Ig G, Ig A, IgMm Imunoglo$ulin: Ig G, Ig A, Ig

    M, Ig *, Ig DM, Ig *, Ig D

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    IMUNOGLO4ULIN GIMUNOGLO4ULIN G

    Ter$ny& 'lm serum [email protected]$ny& 'lm serum [email protected]

    D!# menem$us !lsen#D!# menem$us !lsen# mem$en#u&mem$en#u&

    imuni#s $yi sm!i $erumur C6 $ulnimuni#s $yi sm!i $erumur C6 $uln

    Mem!unyi si(# o!soninMem!unyi si(# o!sonin $er%u$ungn$er%u$ungn

    er# 'engn (gosi#, monosi# 'n m&ro(ger# 'engn (gosi#, monosi# 'n m&ro(g

    4er!ern !' imuni#s seluler4er!ern !' imuni#s seluler '!#'!#

    merus& n#igen selulermerus& n#igen seluler $erin#er&si$erin#er&si'engn &om!lemen, sel K, eosino(il 'n'engn &om!lemen, sel K, eosino(il 'n

    neu#ro(ilneu#ro(il

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    IMUNOGLO4ULIN AIMUNOGLO4ULIN A

    Se'i&i# 'lm serumSe'i&i# 'lm serum

    4ny& #er'!# 'lm4ny& #er'!# 'lm slurn n(s,slurn n(s,

    ern, &emi%, ir m#, &ering#, lu'% 'nern, &emi%, ir m#, &ering#, lu'% 'n

    ir susuir susu 3ungsi3ungsi

    Mene#rl&n #o&sin 'n 5irus,Mene#rl&n #o&sin 'n 5irus,

    Meneg% &on#& n#r #o&sin 5irus 'ng selMeneg% &on#& n#r #o&sin 5irus 'ng sel

    ssrnssrn

    Mengum!l&n menggnggu ger& &umnMengum!l&n menggnggu ger& &umn

    memu'%&n (gosi#osismemu'%&n (gosi#osis

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