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 Rita Evalina Rusli Basic Immunology
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1. Imunologi Dasar New

Feb 28, 2018

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Rita Evalina Rusli

Basic Immunology

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Sejarah Imunologi

Awalnya : cabang mikrobiologiRespons tubuh terutama respons kekebalan

terhadap agen penyebab infeksi  dansubstansi asing dari lingkungan

Yunani, 430 SM, wabah   sembuh  tidakmenderita kedua kalinya

acar : pertama tercatat di hina

!000 SM, tabib hina   menghirup puyeryang terbuat dari krusta lesi cacar  

 "arum#pocking de$ice kekulit %$ariolasi&  'urki dan Asia tengah

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!()* : +dward enner  cowpo- $accination%$acca . sapi&

!**0 : /ouis asteur : attenuated $accines

Robert 1och : 2ypersensiti$ity !)00 : bukti bahwa tubuh memiliki

pertahanan komprehensi terhadap ineksidengan memproduksi antibodi

!)0 : Rodney Robert orter dan 5erald+delman  struktur imunoglobulin

!)60 : renaisance imunologi selular  masuk

era modern

Sejarah ……………

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Sejarah ……………

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Figure 1-33Figure 1-33

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 6

COMPONENTS OF THE IMMUNE RESPONSE

TYPETYPE LOCATIONLOCATION FUNCTIONFUNCTION

B-LymphocyteB-Lymphocyte Lymph nodesLymph nodes

SpleenSpleen

Pe!phe"lPe!phe"l

Re"cts #!th spec!$!c "nt!%ens &Re"cts #!th spec!$!c "nt!%ens &

d!$$eent!"tes !nto pl"sm" cell o memoyd!$$eent!"tes !nto pl"sm" cell o memoy

cellcell

Respons!'le $o "nt!'ody-med!"tedRespons!'le $o "nt!'ody-med!"ted

!mm(n!ty!mm(n!ty

T-lymphocyteT-lymphocyte Lymph nodesLymph nodes

SpleenSpleen

Pe!phe"lPe!phe"l

T!ss(e $l(!dsT!ss(e $l(!ds

Spec!$!c "nt!%en eco%n!t!on to t!%%e cellSpec!$!c "nt!%en eco%n!t!on to t!%%e cell

med!"ted !mm(n!tymed!"ted !mm(n!ty

Mo'!l!)es othe cells tom p"t!c!p"te !n cellMo'!l!)es othe cells tom p"t!c!p"te !n cell

med!"ted !mm(n!tymed!"ted !mm(n!tyHelps e%(l"te !mm(ne esponseHelps e%(l"te !mm(ne esponse

Pl"sm" cellsPl"sm" cells Lymph nodes* SpleenLymph nodes* Spleen

+"sto!ntest!n"l Assoc!"ted+"sto!ntest!n"l Assoc!"ted

Lympho!d T!ss(e ,+ALTLympho!d T!ss(e ,+ALT

Pod(ces "nt!'od!es I%+* I%A* I%E I%M* I%./Pod(ces "nt!'od!es I%+* I%A* I%E I%M* I%./

M"coph"%eM"coph"%e Pe!phe"lPe!phe"lAll t!ss(esAll t!ss(es

00Pesents1 "nt!%ens to B & T lymphocytesPesents1 "nt!%ens to B & T lymphocytesEn%(l$ opson!)ed '"cte!" En%(l$ opson!)ed '"cte!" 

ComplementComplement Blood ,pl"sm" pote!nsBlood ,pl"sm" pote!ns Foms cytolyt!c "nd to2!c comple2es toFoms cytolyt!c "nd to2!c comple2es to

"nt!%en"nt!%en

Med!"tos o$Med!"tos o$

!n$l"mm"t!on!n$l"mm"t!on

−Ne(toph!lsNe(toph!ls−Eos!noph!lsEos!noph!ls 

BloodBlood

T!ss(e !n$l"mm"t!onT!ss(e !n$l"mm"t!on

En%(l$ !mm(ne comple2esEn%(l$ !mm(ne comple2es

Ph"%ocytos!sPh"%ocytos!s

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Origin, differentiation & main function in immunity of hagocytes

7

Bone Marrow stem cells

Lymphoid progenitors Myeloid progenitors Erythroid progenitors Platelet progenitors

Erythrocytes PlateletsT Lymphocyte B Lymphocyte

Granulocytes (In Blood Tissues! Monocytes ( In Blood !

"eutrophils Eosinophils Basophils

Micro#icidalpresentearly inin$lamm

response

%estroyparasitesproducemediators o$

inlammation

&eleasehistamine heparin inanaphylactic

reaction

Macrophages 'leolar  Splenic lymph node

 Lier )up$$er

cells Peritoneal *ther tissues(#rain+ synoia+,idney!

Present late in in$lammresponse

Micro#icidalInitiate immune response

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Figure 1-3Figure 1-3

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Figure 1-3 part 1 of 4Figure 1-3 part 1 of 4

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Figure 1-3 part 2 of 4Figure 1-3 part 2 of 4

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Figure 1-3 part 3 of 4Figure 1-3 part 3 of 4

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Figure 1-3 part 4 of 4Figure 1-3 part 4 of 4

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Elements of the immune systemElements of the immune system

%-

B

-TL

")T

")

M.PM"

nonspeci$ic(innate!

immunityspeci$ic(adaptie!immunity

"*

IgG

IgM

Ig'

IgE

-hemo,ines

Gran/yme

-

T0

s1&eceptors

E*-yto,ines

P&&

Treg

!"#OR$% E%%"%$R  

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'o discriminate self  from non(self 

'o recognise non(self 

'o react to non(self )immunodeficiency*

+unctions of the immune system

'o recognise self 

'o recognise and resond to altered self

)cancer*

'o avoid reacting to harmless antigens )allergy*

'o maintain tolerance to self )autoimmunity*

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Immune system is really a-net .ork/

that involves many differentlayers .hich interact .ith each

other

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+I%O0E1I SIS'E# I#"1 +I%O0E1I SIS'E# I#"1

77 Evolusi perkembangan sistem imun : suatu seri  respons adatif terhadap lingkungan yang

  berubah dan otensial ra.an

7 +$olusi perkembangan sistem imun ditin"au dari

sudut keragaman berbagai macam spesies%paling primiti  paling kompleks : manusia&

7 Seleksi spesies yang paling dapat beradaptasi

  terhadap lingkungan  proses adaptasi : dasar

  ilogeni respons imun

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+I%O0E1I I#"1I'$S 1O1 S2ESI+I3

77 8entuk paling primiti : fagositosis

( Organisme uniseluler, fagositosis

berfungsi nutriti 

7 9rganisme lebih tinggi, agositosis

  berungsi pertahanan

7 ada manusia, 3 dari lekosit yang beredar  )monosit, 2#1 dan eosinofil* berperan

  sebagai agosit

7 Respons inlamasi, pertahanan non spesiik  yang sudah terlihat pada invertebrata

  rimitif 

7 engan e$olusi, bentuk pertahanan

  dipertahankan dan ditambah bentuk lain

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+I%O0E1I I#"1I'$S S2ESI+I3

7 Sudah terlihat pada in$ertebrata primiti 

  %hagish&  berbentuk sistem limfoid  yang tersebar; Antibodi yang terbentuk

  analog dengan Ig#

7 <ertebrata yang tinggi, struktur limoid

  tersendiri

7 <ertebrata yang lebih rendah  Ab yang

  dibentuk mempunyai 8M tinggi %analog dg

  =gM&, pada yang lebih tinggi timbul Ab  kedua yang analog dengan =g5, diikuti

  antibodi yang analog dengan =gA

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+I%O0E1I I#"1I'$S S2ESI+I3…………

7 =munitas seluler sudah terlihat padain$ertebrata dan $ertebrata berupa enolakanterhada jaringan translantasi

7 pada in$ertebrata belum terlihat antibodi yanganalog dengan =g

7 ada manusia : terdapat kelas Ab %=gM, =g5,=gA, =g dan =g+& dengan masing7masingsubkelas

7 Selama e$olusi ter"adi spesialisasi sel yang

berperan spesiik7 >rutan e$olusi kelas imunoglobulin paralel

dengan proses pematangan pada indi$idu

7 Respons imun yang berkembang sempurna  

dengan sesifisitas dan memori imunologik

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+I%O0E1I

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O1'O0E1I SIS'E# I#"1

roses perkembangan sistem imun ditin"au

dari indi$idu yang sedang berkembang : darisel pendahulu  sel matur ada manusia : maturasi respons imun mulai

pd etus ?73 bulan

ierensiasi ungsi imunologik sel nonspesiikdan spesiik %keduanya dari populasi selasal#stem cell&

Stem cell pada embrio : pada "aringan

hematopoietik yolksac1ehamilan 6 minggu : hatiMulai kehamilan ? bulan dan selan"utnya :

sumsum tulang

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1ehamilan 37 bln limpa "g berperan sbg

 "aringan hematopoietik Stlh lahir, sumsum tulang satu7satunya

hematopoietik Sumsum tulang gagal  diambil alih oleh hati

dan limpa 8ergantung pada lingkungan mikro  sel akanberkembang melalui "alur hematopoietik danlimopoietik

alur hematopoietik : eritrosit, granulosit,trombosit dan monosit

alur limopoeitik : sel limosit9ntogeni berkaitan dengan patogenesis

penyakit deisiensi imun terutama deisiensi

imun kongenital

O1'O0E1I ………4

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ONTOGENIONTOGENI

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SPESIFI3NONSPESIFI3

FISI3 LARUT SELULAR HUMORAL SELULAR

• 3ULIT

• SELAPUT

  LEN.IR• SILIA• BATU3• BERSIN

• BIO3IMIA 4 LISO5IM*

SEBASEOUS*

 ASAM LAMBUN+*

LA3TOFERIN* ASAM

NEURAMINI3• HUMORAL 4

3OMPLEMEN* INTER

 FERON* CRP

• FA+OSIT 4

 MN* PMN

• SEL N3• SEL MAST• BASOFIL

SEL B 4• I%+

• I%A• I%M• I%.• I%E

SEL T 4• Th6• Th7• Ts8T8Th9• Tdth• CTL8Tc

SISTEM IMUN

INNATE A.APTI:E

MemoryNo memory

First line of defence Second line of defence

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-omponent o$ innate immunity

  -omponent Principal $unction

 Epithelial layersEpithelial layers

 Mucosal layersMucosal layers Chemicals (enzymeChemicals (enzyme

  gastric aci!s"gastric aci!s"

 Mechanicals (gutMechanicals (gut

  peristaltic mucosalperistaltic mucosal

  cilliary"cilliary"

 #re$ent micro%ial entry

 #re$ent micro%ial entry #re$ent micro%ial entry

 #re$ent micro%ial entry

&on circulating

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-omponent o$…………………

  -omponent Principal $unction

 &eutrophyls&eutrophyls

 MacrophagesMacrophages

 &' cells&' cells

 Early phagocytes an! illing of 

  micro%es Efficient phagocytosis an!

  illing of micro%es secretion

  cytoines that stimulate

  inflamation

 )ysis of infecte! cells acti$ation

  of macrophages

Circulating effectors cells

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-omponent o$…………………

Circulating effectors proteins

 Complement

 Manose-%in!inglectin (collectin"

 C-reacti$e protein

(penta*in"

 Coagulation factors

 'illing of micro%es opsonization of

micro%es acti$ation of leucocytes

 +psonization of micro%es acti$ation  of complement (lectin path,ays"

 +psonization of micro%es acti$ation

  of complement

 alling off of infecte! tissue

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-omponent o$…………………Cytoines

 .&F /)-1 chemoines

 /F&-0

 /)-12

 /)-1

 /)-1 .F-

 /nflamation

 5esistance to $iral infection

 Macrophage acti$ation /F&- pro!uction %y &'

  cells an! . cells

 #roliferation of &' cells

 Control of inflamation

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Innate Immunity 2 in#orn

"on1spesi$ic de$ense against in$ection

 Macrophages+ "eutrophils

 Its action does not depend on prior

e3posure to a particular pathogens Phagocytosis

 

Basic concepts 

Innate Immunity in pathogen elimination

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Innate Immunity in pathogen elimination1 8ateri ulit  langsung !iserang oleh omplemen  eliminasi

2 9e%agian resisten th! er:a omplemen  ati$asi marofag  %eri sinyal e hepar 

3 9inyal imia !ari marofag in!usi hepar untu pro!usi ;##  iat %ateri

4 /atan ;## th! %ateri

 ati$asi omplemen   eliminasi %ateri !an meningatan !aya eliminasi oleh marofag

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Innate Immunity……4

  ;cti$ate Complement system an! they,ill !estroy the pathogen

  ;cute phase proteins pro!uce! %y the

li$er stimulate the macrophage functionagainst infection

.hose protein %in!s to %acterial surface

an! acti$ates complement system toeliminate %acteria !irectly an! enhance

their elimination %y macrophages

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Innate Immunity………

 9ecrete! /)6 %y the macrophage ,ill

  stimulate the li$er  to pro!uce

<acute phase proteins=  ie >

- C-reacti$e protein

- 9erum amyloi! protein

- Mannose %in!ing protein

- Fi%rinogen

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-1reactie protein

C-reacti$e protein %in!s to

#hosphorylcholine on %acterial surfaces

Mannose %in!ing protein %in!s Mannosa

resi!u on %acterial surfaces

C-reacti$e protein an! Mannose %in!ing 

protein respons lie anti%o!y

+psonisation an! acti$ates the

complement casca!e

1 8 t i i ! i i t

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1 8ateri in!usi sintesa

  /)-6 oleh marofag

2 /)-6 %ereasi !engan

sel hepatosit  in!usi

  sintesa ;## termasu

  M8#

1 C5# iat phosphorylcholine pa!a permuaan %ateri

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1 C5# iat phosphorylcholine pa!a permuaan %ateri

2 Manose %in!ing protein iat resi!u manose pa!a permuaan %ateri

  saat sel host eurangan manose ar%ohi!rat

3 C5# %ersama M8# ati$asi omplemen untu lisisan %ateri !an

langsung opsonisasi %ateri

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In$lammatory response

/nfection %acteria trigger macrophagesto release inflammatory me!iators

?aso!ilatation an! increase! $ascular

permea%ility cause re!ness an! heat (ru%or!an calor")eaage of cells an! flui!s cause s,elling

an! pain (tumor !an !olor" 8loo! $essel ,alls %ecome sticy allo,ing

%loo! cells to migrate into tissue.-cells acti$ate! %y macrophages may

sustain chronic inflammation

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IMUNITAS BA;AAN .AN IMUNITAS .I.APATIMUNITAS BA;AAN .AN IMUNITAS .I.APAT

IMUNITAS BA;AAN

@ Pertahanan  lini pertama

@  Ada sejak lahir

@  Non-spes!$!<

IMUNITAS .I.APAT

@ Setelah infeksi/

  aksinasi/dipelajari

@ Sel memori

• Spes!$!<

@ Pertahanan  lini ked!a

PERBE.AAN SISTEM IMUN NONSPESIFI3 .AN SPESIFI3

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PERBE.AAN SISTEM IMUN NONSPESIFI3 .AN SPESIFI3

NONSPESIFI3

POSITIF 4 SELALU

SIAP* RESPONS

CEPAT* TI.A3 PERLU

PA=ANAN

SEBELUMNYA

NE+ATIF 4 .APAT

BER >>* MEMORI ??

SPESIFI3

NE+ATIF 4 TI.A3 SIAP

SAMPAI TERPA=AN ALER+EN *

RESPONS LAMBAT

POSITIF 4 RESPONS INTENS*

PERLIN.UN+AN LEBIH BAI3 PA.A

PA=ANAN BERI3UT

PRESENTASI ANTI+EN

  SITO3IN

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SISTEM IM"N NON SPESI#I$SISTEM IM"N NON SPESI#I$

Terse%ar disel!r!h t!%!h

&alam s!ms!m t!lan'( tim!s( darah( $G)(

limpa( sal nafas( sal *erna( sal kemih dan

 jarin'an

)erasal dari sel prek!rsor m!ltipoten dalam

s!ms!m t!lan'

SISTEM IMUN

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FA+OSITBASOFIL .AN

 SEL MAST

SISTEM IMUN

 NONSPESIFI3

NULL CELL* SEL 3

.AN SEL N3

PMNMN

MONOSIT

MA3ROFA+

FA+OSITOSIS

NETROFIL

EOSINOFIL

 

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Me<"n!sme espons !m(n '"#""n

Innate immunity 

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Im(n!t"s l"h!!"hIm(n!t"s l"h!!"hTop!<

• Pertahanan fisis( kimia+i dan %iolo'is

• ,at-.at anti-infektif alamiah

• #a'ositosis

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Pet"h"n"n $!s!s* <!m!"#! d"n '!olo%!sPet"h"n"n $!s!s* <!m!"#! d"n '!olo%!s

@8arier fisis

@8arier imia,i@Flora %aterial

)ulit@ 8arier fisis

@ 8arier imia,i

Mem#ran mu,osa

@ Mem%ran muosa

@ ;sam !an %asa

@ Flora %aterial

  Saluran cerna

@ Mem%ran muosa

@ Epitel %ersilia

Saluran respiratori

Me<"n!sme espons !m(n '"#""n Innate immunity 

5 t t! ! $ <t!$ l ! h5"t "nt! !n$e<t!$ "l"m!"h

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5"t "nt! !n$e<t!$ "l"m!"h5"t "nt! !n$e<t!$ "l"m!"h

•  Anti-bacterial agentsLyso)yme

Ada dalam air mata( salia(makrofa'(limpa Men'han*!rkan dindin' %akteri sel

•  Anti-viral agents 

Inte$eon &isintesis %ila ada infeksi ir!s Men'ham%at replikasi ir!s

3omplemen

Men'han*!rkan dindin' %akteri sel Mem%ant! destr!ksi pato'en

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.he specificity of innate immunity an! a!apti$e immunity.he specificity of innate immunity an! a!apti$e immunity

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Functions of epithelia in innate immunityFunctions of epithelia in innate immunity 

Th $ t ! th ! t! $ 'l d l < t t !t $ ! $ t!

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The se@(ence o$ eents !n the m!%"t!on o$ 'lood le(<ocytes to s!tes o$ !n$ect!on  

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Functions of natural iller (&'" cellsFunctions of natural iller (&'" cells

Innate Immunity in pathogen elimination

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Innate Immunity in pathogen elimination

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Resepto d"n $(n%s! espons $"%os!tos!s m"<o$"%

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Resepto d"n $(n%s! espons $"%os!tos!s m"<o$"%

Adhesipd endotel

Migrasike jaringan

Mikrobadimusnahkan

Mikrobadimusnahkan

Reseptor Transmembran

Seven α-helical

Reseptor Toll-like Reseptor

fagositik

AviditasIntegrin

Perubahansitoskeletal

Respiratory burst 

FagositosisMikroba pd fagosom

Reactive oxygenIntermediate (ROIs)

LPS

CD 14

Mediatorlipid

Kemokin

PeptidaN-orm!lmethion!l

Sel sel y% 'epe"n p"d" s!stem <e<e'"l"n t('(hSel-sel y% 'epe"n p"d" s!stem <e<e'"l"n t('(h

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Sel-sel y%/ 'epe"n p"d" s!stem <e<e'"l"n t('(hSel-sel y%/ 'epe"n p"d" s!stem <e<e'"l"n t('(h

6/ Sel l!m$os!t 4 Sel T d"n Sel B6/ Sel l!m$os!t 4 Sel T d"n Sel B

  Sel T 0  Sel T 0 - Sel T- Sel T helperhelper 1 sel T231 sel T23  - Sel T- Sel T supressorsupressor 1 sel T4 31 sel T4 3

  Sel limfosit non T( non )0 sel Nat!ral $iller 1 N$ 3  Sel limfosit non T( non )0 sel Nat!ral $iller 1 N$ 3

7/ Sel $"%os!t , sel pen%h"nc( m!<o'"7/ Sel $"%os!t , sel pen%h"nc( m!<o'"

  - Sel ne!trofil 1le!kosit %erinti %anyak3- Sel ne!trofil 1le!kosit %erinti %anyak3

- Sel eosinofil 0 %erperan pada inf5 parasit serta- Sel eosinofil 0 %erperan pada inf5 parasit sertapada reaksi aler'ipada reaksi aler'i

- Sel monosit/makrofa' 0 %erinti sat!  - Sel monosit/makrofa' 0 %erinti sat!

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Poses $"%os!tos!s 9 t"h"pa5 Per'erakan le!kosit ke tempat k!man %erada

%5 Pen'ikatan k!man oleh anti%odi 1opsonisasi3*5 Pen'el!aran en.im oleh le!kosit !tk5  men'han*!rkan k!man y' s!dah ditelan

9/ Sel '"so$!l d"n sel m"st9/ Sel '"so$!l d"n sel m"st  - Men'and!n' .at histamin dll5- Men'and!n' .at histamin dll5

- )erperan pd reaksi peradan'an 6 reaksi aler'i  - )erperan pd reaksi peradan'an 6 reaksi aler'i

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F"%os!tos!sF"%os!tos!s

F"%os!tP"tho%en F"%os!t-hemota3isAtt"chment)illing.!%est!on

Imunitas alami (Innate immunity)

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F"%os!tos!s 4 Sel netrofil( makrofa'( PMN menelan pato'en

!nt!k *e'ah infeksi5 7 89 j!ta sel %erada di sirk!lasi 6 jarin'anyan' melapisi pem%!l!h darah par!( hati( $G) 6 limpa5

Poses $"%os!tos!s mel!'"t<"n4

$emotaksisMakrofa' kontak d'n pato'en menelan m!snahkan

Mem!snahkan j!taan pato'en di jarin'an dlm %%rp menit

)erperan se%a'ai jem%atan antara im!nitas alami dan

im!nitas didapat den'an memproses dan

mempresentasikan pato'en pada sel limfosit T

Imunitas alami (Innate immunity)

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Ant!%enAnt!%en

Ant!%en "d"l"h 4

• S!%stansi yan' memi*! respon im!n 1im!no'en3

• :non-self’ 

• )iasanya molek!l %esar( *omple;

• Serin' terdiri dari protein ata! polisakarida

ata! kom%inasi ked!anya den'an lipidir!s dan %akteri

< ! !S < A ! !

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St(<t( Ant!%en ep!topeSt(<t( Ant!%en ep!tope

0epatitis B irus

S($"ce "nt!%en ,HBsA%

Pe-S6 "nd pe-S7 "nt!%en

eD "nt!%en ,HBeA%

Coe "nt!%en ,HBcA%

Bordetella

 pertussis

Pet(ss!s to2!n

F!l"mento(s h"em"%%l(t!n!n

Pet"ct!n

F!m'!"l "nt!%ens

3ESIMPULAN IMUNITAS BA;AAN

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3ESIMPULAN IMUNITAS BA;AAN

<5<5 #aktor fisik( %iokimia#aktor fisik( %iokimia

=5=5 #a'ositosis( sel dendrit( netrofil#a'ositosis( sel dendrit( netrofil

>5>5

InterferonInterferon

2525 ?y.osim?y.osim

8585 $omplemen$omplemen

@5@5 Sifat tidak spesifikSifat tidak spesifik

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)ellanti A5 Imm!nolo'y III

Stites &P( Terr AI( Parslo+ TG5 Medi*al Imm!nolo'y

A%%as A$( ?i*htman A5)asi* Imm!nolo'y

Boitt I( )rostof C( Male &5 Imm!nolo'y

REFERENSI

Me<"n!sme espon !m(n d!d"p"tMe<"n!sme espon !m(n d!d"p"t

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Me<"n!sme espon !m(n d!d"p"tMe<"n!sme espon !m(n d!d"p"t

Cell-med!"ted

,Sel(l"

@ Mempol!$e"s! sel-sel•<h(s(s

.!t((<"n teh"d"p "nt!%en

d! d"l"m sel

@ .!-med!"s! oleh l!m$os!t T @ .!med!"s! oleh l!m$os!t B

  ,L!m$os!t-T (%" tel!'"t

Ant!'ody-med!"ted

,H(mo"l

@ Men%h"s!l<"n pote!n

 <h(s(s ,"nt!'od!

@ .!t((<"n teh"d"p "nt!%en

s!<(l"s!

S"t( t!l!(n sel l!m$os!t tet"p 'e"d" d! s!<(l"s!

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S(ms(m t(l"n%

  Sel Stem

Pem"t"n%"n

d! Thym(s

Pem"t"n%"n d! S/S/TL

Sel l!m$os!t TSel l!m$os!t B

p

S!<(l"s! l!m$os!tS!<(l"s! l!m$os!t

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S!<(l"s! l!m$os!tS!<(l"s! l!m$os!t

Limpa)elenjar 

lim$e

Sumsum tulang

Thymus

Blood stream

$lon ekspansi

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Pool l!m$os!t !m"t(

M"s!n%-m"s!n% 'e'ed" 

."p"t men%en"l 6 (t" A%

:!(s

A% spes!$!<

menst!m(l"s!l!m$os!t

3lon l!m$os!t

Sem(" l!m$os!t s"m" 

$lon ekspansi

Respons !m(n p!me d"n se<(nde

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Respons !m(n p!me d"n se<(nde

Ap"<"h espons !m(n p!me d"n espons !m(n se<(ndeG

1 ! " # $

3ont"< pet"m" 3ont"< <ed("  

%ali

Intens!t"sespons

 !m(n I%M

I%+

Respons !m(n p!me d"n se<(nde

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p p

Paparan Ag

Pertama kali

Paparan Ag

%edua kali

Sel &aktif 

Sekresi Abdr sel plasma

Responsprimer

'ong livedPlasma cell

(in &M)

Sel &memori

Sel & aktif 

Responsprimer

Responssekunder

*ari setelah paparan Ag *ari setelah paparan Ag

'ong livedPlasma cell

(in &M)

Sel &memori

   +  u  m   l  a   h  a  n   t   i   b  o   d   i

SekresiAb dari

Sel plasma

$omponen sistem keke%alan t!%!h$omponen sistem keke%alan t!%!h

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$omponen sistem keke%alan t!%!ho po e s ste e e%a a t!%!

S!stem <e<e'"l"n h(mo"l ,I%M* I%+* I%A* I%E* I%.S!stem <e<e'"l"n h(mo"l ,I%M* I%+* I%A* I%E* I%.

Im(no%lo'(l!n M 4- )erperan pada reaksi keke%alan a+al mis5 Infeksi- )erperan pada reaksi keke%alan a+al mis5 Infeksi

tahap a+al5tahap a+al5

- Tidak dapat melal!i plasenta- Tidak dapat melal!i plasenta Im(no%lo'(l!n +4

 - )erperan pada reaksi keke%alan sek!nder 1lanj!tan3- )erperan pada reaksi keke%alan sek!nder 1lanj!tan3

Im(no%lo'(l!n A 4 - Pada perm5 sel5 lendir mis5sal5 *erna 1I'A sekretorik3 ata!- Pada perm5 sel5 lendir mis5sal5 *erna 1I'A sekretorik3 ata!

  sal5 napassal5 napas

Im(no%lo'(l!n E4- Menempel p"d" sel m"st ,'epe"n p"d" e"<s! pe"d"n%"n8

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- Menempel p"d" sel m"st ,'epe"n p"d" e"<s! pe"d"n%"n8

"le%! * 'e<e" s"m" den%"n sel eos!no$!l men%h"nc(<"n

p""s!t

Im(no%lo'(l!n . 4- 3"d"ny" s"n%"t <ec!l* $(n%s! 'el(m el"s

S!stem <e<e'"l"n sel(l" ,Cell Mediated Immunity/ CMI  4

.!pe"n<"n oleh sel T d"n monos!t8m"<o$"% 3ont"< "nt" sel mel"l(! s!to<!n Bepe"n p"d" !n$e<s! <on!< te(t"m" !n$e<s! <(m"n d"l"m sel

m!s/ T'c* !(s set" "m(

S!stem <omplemen Mempe<("t pet"h"n"n t('(h spes!$!< d"n non spes!$!</ .!"<t!$<"n mel"l(! "l( <l"s!< d"n "l( "lten"t!$/